Association of Predisposing Haplotype Snp-Markers of HBB Gene in Thalassaemia

Most of the beta thalassaemia cases are heterogeneous at molecular level. The genetic variation arises due to mutation a single beta-globin gene (HBB) on chromosome 11p15.5. Eventhough, basis and natural history this disorder still not well understood clinical presentation in certain patients was always correlated with diagnosis [1].
 
 study aimed evaluate predisposing effect HBB polymorphisms their haplotypes conferring beta-thalassaemia Malaysia using bioinformatics tool. Archived genotype data for five tagging SNPs assigned as c.9T/C, IVS2-16G/C, IVS2-74T/G, 3'UTR +314G/A +316A/C across patient group (n=433) normal control (n=794) controls were retrieved from year 2011 2016 Institute Medical Research (IMR). analysed individual SNP-based association analysis haplotype-based SHEsis online software.
 all races showed significant four (c.9T/C, P-value = 0.014; 0.017; 3'UTR+314G/A, P value 2.08x108; 3'UTR+316A/C, 0.021). However, IVS2-74T/G did show 0.763 (Table 1). We further revealed two susceptible (haplotype TGTAA, 1.68x10-7, OR 2.382 [1.707~3.325]; haplotype CCTGC, 0.003, 1.300 [1.089~1.551]). Meanwhile, one protective observed TGTGA (P-value 2.99x10-7, 0.625 [0.522~0.749]) 2).
 In conclusion, suggests potential